منابع مشابه
Workshop in Genetics of Neurodegenerative Diseases
Year 2006 will be the year of celebrations of dementia research and neuroscience in Finland. In November 1907 Alois Alzheimer presented the neuropathological features in a patient with an early-onset dementia, Auguste D, in a medical conference. The disease characterized with neuritic plaques and neurofibrillary tangles in the brain and slowly evolving dementia as a clinical phenotype has since...
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In addition to sharing several clinical, pathologic, and molecular characteristics, many neurodegenerative disorders show extensive familial histories suggesting a substantial contribution of genetic factors to disease causation and progression. In this review, the authors provide overviews of the status of current genetics research in Alzheimer's disease, Parkinson's disease, frontotemporal de...
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During the past three decades, we have witnessed remarkable advances in our understanding of the molecular etiologies of hereditary neurodegenerative diseases, which have been accomplished by 'positional cloning' strategies. The discoveries of the causative genes for hereditary neurodegenerative diseases accelerated not only the studies on the pathophysiologic mechanisms of diseases, but also t...
متن کاملneurodevelopmental basis of neurodegenerative diseases
the human brain is composed of several interconnected, functionally distinct structures and much debate has surrounded the basic question of how these structures evolve. brain development begins in early gestation. between 4 weeks and 9 months, brain undergoes rapid development. there are six stages of nervous system development. brain increases connections between birth and 21 years of age. ab...
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ژورنال
عنوان ژورنال: Neurology Genetics
سال: 2016
ISSN: 2376-7839
DOI: 10.1212/nxg.0000000000000052